Overview of Metronidazole Toxicity in Cats

1 Overview

It is also used to treat severe infections, usually in combination with other antibiotics. Unfortunately, like all drugs, metronidazole toxicity and adverse reactions occur from time to time. However, metronidazole toxicity is uncommon and is usually associated with long-term use (weeks) or high-dose intake. Cats with underlying liver disease are more prone to metronidazole poisoning. Metronidazole toxicity affects the cat’s brain and body balance.

Symptoms of Metronidazole Toxicity in Cats

Symptoms usually include neurological damage, such as: difficulty walking, stumbling, head tilt. Some cats also show gastrointestinal symptoms such as: vomiting, diarrhea, and loss of appetite. Liver poisoning is relatively rare. In addition, related symptoms include:

1. Not eating (anorexia)

2. Vomiting

3. Diarrhea

4. Drooling (ptyalism)

5. Stumbling or difficulty walking

6. Involuntary and continuous eye movement (nystagmus)

7. Head tilt

8. Lethargy

9. Seizures

10. Low neutrophil count (neutropenia)

11. Pigmenturia

12. Signs of liver poisoning

Diagnosis of Metronidazole Toxicity in Cats

Diagnosis of metronidazole toxicity is based on physical examination results and recent medication history. Blood tests to assess metronidazole toxicity levels are not effective and are rarely used.

Treatment of Metronidazole Toxicity in Cats

1. The initial treatment for metronidazole poisoning is to stop all medication immediately.

2. Depending on the severity of toxicity, some cats may need hospitalization and intravenous fluids.

3. Intravenous diazepam (valium) can be used to control seizures and help improve the cat’s neurological symptoms.

4. Medication to relieve vomiting may also be needed.

5. Blood tests may be needed to assess liver and kidney function.

6. There is no specific antidote for metronidazole toxicity; recovery may take 1-2 weeks.

7. Some cats with severe metronidazole poisoning may not survive.

Home Care and Prevention of Metronidazole Toxicity in Cats

There is currently no home care information for metronidazole toxicity in cats. If you suspect metronidazole is making your cat sick, consult your veterinarian before stopping the medication; you may need an alternative treatment for the original infection being treated with metronidazole.

Always use all medications for your cat strictly as prescribed by your veterinarian. Do not give your cat extra doses of metronidazole unless specifically instructed by your veterinarian.